Afzelin

SKU: orb1297471

Description

Afzelin

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 482-39-3
• MW: 432.38
• Purity: 98.92%
• Formula: C₂₁H₂₀O₁₀
• SMILES: C[C@H]1OC(Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@@H](O)[C@@H](O)[C@@H]1O
• Target: PTEN,TNF,Antibacterial,p38 MAPK,Autophagy,Prostaglandin Receptor,Mitochondrial Metabolism
• Solubility: Ethanol:12 mg/mL (27.75 mM)

Bioactivity

• In Vitro:
  Therefore, in this study, we investigated the protective effects of Afzelin, one of the flavonoids, against UV irradiation in human keratinocytes and epidermal equivalent models. Spectrophotometric measurements revealed that the Afzelin extinction maxima were in the UVB and UVA range, and UV transmission below 376 nm was <10%, indicating UV-absorbing activity of Afzelin. In the phototoxicity assay using the 3T3 NRU phototoxicity test (3T3-NRU-PT), Afzelin presented a tendency to no phototoxic potential. In addition, in order to investigate cellular functions of Afzelin itself, cells were treated with Afzelin after UVB irradiation. In human keratinocyte, Afzelin effectively inhibited the UVB-mediated increase in lipid peroxidation and the formation of cyclobutane pyrimidine dimers. Afzelin also inhibited UVB-induced cell death in human keratinocytes by inhibiting intrinsic apoptotic signaling. Furthermore, Afzelin showed inhibitory effects on UVB-induced release of pro-inflammatory mediators such as interleukin-6, tumor necrosis factor-α±, and prostaglandin-E2 in human keratinocytes by interfering with the p38 kinase pathway. Using an epidermal equivalent model exposed to UVB radiation, anti-apoptotic activity of Afzelin was also confirmed together with a photoprotective effect at the morphological level

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNF-α, ProstaglandinReceptor, Prostaglandin Receptor, PTEN-induced kinase 1 (PINK1), PTEN, PGE, Phosphatase and tensin homolog, Kaempferol-3-O-rhamnoside, inhibit, p38, p38 MAPK, p38MAPK, MitochondrialMetabolism, Mitochondrial Metabolism, MMAC1, Inhibitor, Bacterial, Autophagy, Afzelin

Compound Identifiers

PubChem CID

22838616