AF615

SKU: orb2279879

Description

AF615 is a potent small-molecule disruptor of the CDT1/Geminin interaction, exhibiting IC50 values of 0.313 μM. This compound demonstrates selective genotoxic effects in cancer cells, including DNA synthesis inhibition, cell cycle arrest, and reduced viability. Binding studies reveal differential affinity for protein variants (Ki = 0.37 μM for Geminin-tCDT1 vs 0.75 μM for Geminin-miniCDT1).

Key Properties

• CAS Number: 122510-61-6
• MW: 267.307
• Purity: >98%
• Formula: C₁₀H₁₃N₅O₂S
• SMILES: O1CCN(C(=S)NNC(C2=CN=CC=N2)=O)CC1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

830141