AF3485

SKU: orb2664580

Description

AF3485 is a selective mPGES-1 inhibitor that suppresses tumor growth by blocking PGE2 production and downstream EGFR, VEGF, and FGF-2 signaling. It has demonstrated anti-angiogenic and anti-tumor efficacy in both in vitro assays and in vivo A431 xenograft mouse models.

Key Properties

• CAS Number: 1195786-61-8
• MW: 398.38
• Formula: C₂₂H₁₇F₃N₂O₂
• SMILES: O=C(NC1=CC=C2C(=C1)C=3C=CC=CC3N2CCO)C=4C=CC=CC4C(F)(F)F

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

44469536