AF-353

SKU: orb1306512

Description

AF-353 (Ro-4) is a potent, orally bioavailable P2X3 and P2X2/3 receptor antagonist, exhibiting high affinity for human and rat P2X3 receptors (pIC50=8.0). This compound is a valuable research tool for investigating the role of these receptors in pain, cough, and inflammation in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 865305-30-2
• MW: 400.21
• Purity: 99.35% (May vary between batches)
• Formula: C₁₄H₁₇IN₄O₂
• SMILES: COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I
• Target: P2X Receptor
• Solubility: DMSO:55 mg/mL (137.43 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5 mM)

Bioactivity

• Target IC50:
  P2X3 (human):7.3 (pIC50)|P2X3 (rat):8.0 (pIC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AF353, AF-353, AF 353, inhibit, Inhibitor, P2X Receptor, P2X3, P2XRs, P2XReceptor, Ro4, Ro-4, Ro 4

Compound Identifiers

PubChem CID

15953802