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AF-353

SKU: orb1306512

Description

AF-353 (Ro-4) is a potent, orally bioavailable P2X3 and P2X2/3 receptor antagonist, exhibiting high affinity for human and rat P2X3 receptors (pIC50=8.0). This compound is a valuable research tool for investigating the role of these receptors in pain, cough, and inflammation in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number865305-30-2
MW400.21
Purity97.95% (May vary between batches)
FormulaC14H17IN4O2
SMILESCOc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I
TargetP2X Receptor
SolubilityDMSO:55 mg/mL (137.43 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5 mM)

Bioactivity

Target IC50
P2X3 (human):7.3 (pIC50)|P2X3 (rat):8.0 (pIC50)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AF353, AF-353, AF 353, inhibit, Inhibitor, P2X Receptor, P2X3, P2XRs, P2XReceptor, Ro4, Ro-4, Ro 4

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 120.00
25 mg
$ 200.00
50 mg
$ 260.00
100 mg
$ 360.00
200 mg
$ 490.00
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