AES-135

SKU: orb1310018

Description

AES-135 is a potent small molecule inhibitor of HDAC3, HDAC6, and HDAC11 with IC50 values of 654, 190, and 636 nM, respectively. It exhibits anti-tumor activity and is a useful research tool for studying epigenetics and oncology in both cellular and animal models of cancer.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2361659-61-0
• MW: 693.66
• Purity: 98.01% (May vary between batches)
• Formula: C₃₃H₂₉F₆N₃O₅S
• SMILES: CC(C)(C)c1ccc(CN(C(=O)CN(Cc2c(F)c(F)c(F)c(F)c2F)S(=O)(=O)c2ccc(F)cc2)c2ccc(cc2)C(=O)NO)cc1
• Target: HDAC
• Solubility: DMSO:100 mg/mL (144.16 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (4.76 mM)

Bioactivity

• Target IC50:
  HDAC11:636 nM|HDAC3:654 nM|HDAC6:190 nM|HDAC8:1100 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AES135, AES-135, AES 135, anti-tumor, inhibit, pancreatic, Inhibitor, HDAC, HDAC11, HDAC3, HDAC6, Histone deacetylases

Compound Identifiers

PubChem CID

137628685