Aegeline

SKU: orb1299452

Description

Aegeline is an alkaloidal amide isolated from Aegle marmelos leaves. It has demonstrated antihyperglycemic and antidyslipidemic effects in validated animal models of type 2 diabetes. Research applications include in vivo metabolic disease studies and in vitro investigations into its mechanisms of action.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 456-12-2
• MW: 297.35
• Purity: 99.98% (May vary between batches)
• Formula: C₁₈H₁₉NO₃
• SMILES: COc1ccc(cc1)C(O)CNC(=O)\C=C\c1ccccc1
• Target: Antifungal
• Solubility: DMSO:25 mg/mL (84.08 mM);10% DMSO+90% Corn Oil:2 mg/mL (6.73 mM)

Bioactivity

• In Vitro:
  Aegeline enhanced GLUT4 translocation mediated 2-deoxy-glucose uptake in both time and concentration-dependent manner. 2-deoxy-glucose uptake was completely stymied by the transport inhibitors (wortmannin and genistein) in C2C12 myotubes. Pharmacological inhibition of Akt (also known as protein kinase B) and Ras-related C3 botulinum toxin substrate 1 (Rac1) suggest that both Akt and Rac1 operate aegeline-stimulated glucose transport via distinct parallel pathways. Moreover, aegeline activates p21 protein-activated kinase 1 (PAK1) and cofilin (an actin polymerization regulator). Rac1 inhibitor (Rac1 inhib II) and PAK1 inhibitor (IPA-3) completely blocked aegeline-induced phosphorylation of cofilin and p21 protein-activated kinase 1 (PAK1).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aegeline, inhibit, Fungal, Inhibitor, SNARE, toxicity, protein, yeast, Sec22p, αsyn

Compound Identifiers

PubChem CID

15558419