ADU-S100

SKU: orb1710481

Description

ADU-S100

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 1638241-89-0
• MW: 690.54
• Purity: 99.83% (May vary between batches)
• Formula: C₂₀H₂₄N₁₀O₁₀P₂S₂
• SMILES: O[C@H]1[C@]2([H])[C@H](N3C4=NC=NC(N)=C4N=C3)OC1([H])CO[P@@](O[C@]5([H])[C@@](O[C@@H](N6C7=NC=NC(N)=C7N=C6)[C@@H]5O)([H])CO[P@](O2)(S)=O)(S)=O
• Target: Others,TNF,STING,IL Receptor,COX,IκB/IKK
• Solubility: DMSO:1 mg/mL (1.45 mM);H2O:16 mg/mL (23.17 mM)

Bioactivity

• In Vivo:
  Methods: SNI male and female mice were treated with ADU-S100 (35 nmol, intrathecal injection), and the expression of IFN-I and induced NF-κB genes in the dorsal horn tissue of mice treated with PBS or ADU-S100 after SNI was analyzed. Results: Transcripts of the proinflammatory cytokines IL-1β, TNFα, and CCL2 showed significant increases only in female mice treated with ADU-S100.
• In Vitro:
  Methods: DCs were treated with ADU-S100 (3.125, 6.25, 12.5, 25, 50, 100, 200 ng/mL) and activated to validate the activity of ADU-S100 and optimize the ideal dose for further assays. Results: The expression of co-stimulatory molecules CD40, CD86, and MHC II increased in a dose-dependent manner, indicating successful DC maturation.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADU-S-100, ADU-S100, ADU-S 100, ADUS100, ADU S100, MIW 815, MIW815, MIW-815, ML RR-S2 CDA, STING

Compound Identifiers

PubChem CID

137699075