ADT-007

SKU: orb2282952

Description

ADT-007 is a selective, orally bioavailable pan-RAS inhibitor that suppresses oncogenic signaling by blocking GTP binding. It demonstrates potent antitumor activity in preclinical models of gastrointestinal cancers, inhibiting MAPK/AKT pathways in both in vitro and in vivo studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1945941-09-2
• MW: 449.47
• Purity: 97.75%
• Formula: C₂₆H₂₄FNO₅
• SMILES: C(=C/1\C=2C(C(CC(NCC3=CC=CO3)=O)=C1C)=CC(F)=CC2)\C4=CC(OC)=C(O)C(OC)=C4
• Target: Ras

Bioactivity

• In Vivo:
  In 6-8-week-old BALB/C mice injected with colorectal cancer cells, ADT-007 (10 mg/kg; intra-tumoral injection; once a day; for 17-21 days) can strongly inhibit tumor growth.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADT 007, ADT007, RAS

Compound Identifiers

PubChem CID

121393631