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ADS032

SKU: orb2900411
FeaturedFeatured Product

Description

ADS032 is a dual NLRP1/NLRP3 inhibitor that rapidly and reversibly blocks inflammasome formation, suppressing IL-1β and TNF-α production in human immune and epithelial cells. It reduces NLRP3-driven ASC speck formation, protects mice from lethal influenza A by dampening lung inflammation, and inhibits Nigericin-induced IL-1β secretion (IC₅₀ = 94.6 μM, no washout; 354 μM, washout).

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Key Properties

CAS Number2757333-37-0
MW403.54
Purity>98% (HPLC)
FormulaC22H29NO4S
SMILESO=C(O)CCCC1=CC=C(C=C1)C=2C=CC(=CC2)S(=O)(=O)N(CCC)CCC
TargetNOD
SolubilityDMSO : 100 mg/mL (247.81 mM; Ultrasonic )

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • ADS032 [orb1980177]

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    2757333-37-0

    403.54

    C22H29NO4S

    100 mg, 50 mg, 10 mg, 1 mg, 5 mg, 25 mg, 1 ml x 10 mM (in DMSO)
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Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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ADS032 (orb2900411)

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Available Sizes

Select a size below

500 mg
2 mg
$ 110.00
5 mg
$ 150.00
10 mg
$ 230.00
25 mg
$ 410.00
50 mg
$ 680.00
100 mg
$ 1,050.00