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ADS032
Catalog Number: orb2900411
| Catalog Number | orb2900411 |
|---|---|
| Category | Small Molecules |
| Description | ADS032 is a dual NLRP1/NLRP3 inhibitor that rapidly and reversibly blocks inflammasome formation, suppressing IL-1β and TNF-α production in human immune and epithelial cells. It reduces NLRP3-driven ASC speck formation, protects mice from lethal influenza A by dampening lung inflammation, and inhibits Nigericin-induced IL-1β secretion (IC₅₀ = 94.6 μM, no washout; 354 μM, washout). |
| Target | NOD |
| Purity | >98% (HPLC) |
| MW | 403.54 |
| Solubility (25°C) | DMSO : 100 mg/mL (247.81 mM; Ultrasonic ) |
| CAS Number | 2757333-37-0 |
| Formula | C22H29NO4S |
| SMILES | O=C(O)CCCC1=CC=C(C=C1)C=2C=CC(=CC2)S(=O)(=O)N(CCC)CCC |
| Storage | Storage temperature: -20°C. Stability: ≥ 2 years |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
ADS032 [orb1980177]
99.33%
2757333-37-0
403.54
C22H29NO4S
50 mg, 100 mg, 10 mg, 1 mg, 5 mg, 25 mg, 1 ml x 10 mM (in DMSO)
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.Note:
- For Reference Only. Please choose the appropriate dissolution protocol according to your experimental animal and administration method.
- We suggest that in cell experiments, the final concentration of DMSO is not more than 0.1%, in animal experiments, for healthy mice, the final concentration of DMSO is not more than 10%; For nude or frail mice, the final concentration of DMSO is not more than 2%.
