ADR-925

SKU: orb1698729

Description

ADR-925 is the active, iron-chelating metabolite of dexrazoxane. It is used in research to protect against doxorubicin-induced cardiotoxicity, as demonstrated in studies using neonatal rat cardiomyocytes in vitro and in various animal models in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 75459-34-6
• MW: 304.3
• Purity: 98.00%
• Formula: C₁₁H₂₀N₄O₆
• SMILES: N([C@H](CN(CC(N)=O)CC(O)=O)C)(CC(N)=O)CC(O)=O
• Target: Endogenous Metabolite

Bioactivity

• In Vivo:
  METHODS: ADR-925 (ICRF 198) (88 mg/kg, intraperitoneal injection, 30 minutes before doxorubicin injection, once a week, 12 times) was administered to mice to observe the protective effect of ADR-925 against the lethal effects of mice. RESULTS In animals pretreated with ADR559, there was partial protection against the lethal effects of doxorubicin.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ICRF198, ICRF-198, ICRF 198, EndogenousMetabolite, ADR925, ADR-925, ADR 925, Endogenous Metabolite

Compound Identifiers

PubChem CID

10402764