Aderbasib

SKU: orb2695152

Description

Aderbasib (INCB007839) is a potent, orally bioavailable dual inhibitor of ADAM10 and ADAM17. It is utilized in cancer and cardiovascular research, where its activity in blocking ectodomain shedding has been investigated in both cellular assays and in vivo tumor models.

Research Area

Immunology & Inflammation, Protein Biochemistry

Key Properties

• CAS Number: 791828-58-5
• MW: 416.47
• Purity: 99.15% (May vary between batches)
• Formula: C₂₁H₂₈N₄O₅
• SMILES: C(NO)(=O)[C@H]1CC2(CN(C(OC)=O)[C@@H]1C(=O)N3CCN(CC3)C4=CC=CC=C4)CC2
• Target: ADAM,MMP,Immunology/Inflammation related
• Solubility: DMSO:80 mg/mL (192.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.92 mM)

Bioactivity

• In Vivo:
  Aderbasib (60 mg/kg/day, tube feeding) combined with EP (0.5 mg/kg, ip) or PEPDG278D (4 mg/kg, ip) inhibited the growth of HCT116 and HT29 tumors.
• In Vitro:
  Aderbasib inhibits the shedding of all EGFR ligands by inhibiting ADAM10 and ADAM17. Aderbasib significantly reduced soluble HB-EGF levels in tumor tissue.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aderbasib, INCB007839, INCB-007839, INCB 7839, INCB7839, INCB-7839, INCB 007839

Compound Identifiers

PubChem CID

16070111