Adenosine receptor antagonist 6

SKU: orb3136376

Description

Adenosine receptor antagonist 6 is an orally active, selective (S)-enantiomer compound that acts as an A2A adenosine receptor (A2AAR) antagonist. It binds to the A2A adenosine receptor with a Ki value of 19.18 nM. This antagonist inhibits cAMP production mediated by 5’-N-ethylcarboxamide adenosine (NECA) with an IC50 value of 0.089 μM and reduces immunosuppression, while enhancing the secretion of IL-2 and IFN-γ. It counteracts adenosine-induced immunosuppression in T cell activation and cytokine release and inhibits tumor growth in CT26/MC38 xenograft models, making it applicable for colorectal cancer research.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2913578-04-6
MW	332.36
Formula	C₁₈H₁₆N₆O
SMILES	NC=1C=2N(C=3C(N2)=CC=CC3)C=C(C(N[C@@H](C)C4=CC=CC=N4)=O)N1
Target	Interleukin,IFNAR,Adenosine Receptor,Cytochromes P450

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Interleukin,IFNAR,Adenosine Receptor,Cytochromes P450

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