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Adenosine receptor antagonist 6

SKU: orb3136376

Description

Adenosine receptor antagonist 6 is an orally active, selective (S)-enantiomer compound that acts as an A2A adenosine receptor (A2AAR) antagonist. It binds to the A2A adenosine receptor with a Ki value of 19.18 nM. This antagonist inhibits cAMP production mediated by 5’-N-ethylcarboxamide adenosine (NECA) with an IC50 value of 0.089 μM and reduces immunosuppression, while enhancing the secretion of IL-2 and IFN-γ. It counteracts adenosine-induced immunosuppression in T cell activation and cytokine release and inhibits tumor growth in CT26/MC38 xenograft models, making it applicable for colorectal cancer research.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2913578-04-6
MW332.36
FormulaC18H16N6O
SMILESNC=1C=2N(C=3C(N2)=CC=CC3)C=C(C(N[C@@H](C)C4=CC=CC=N4)=O)N1
TargetInterleukin,Adenosine Receptor,Cytochromes P450,IFNAR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information