Adefovir

SKU: orb1299812

Description

Adefovir is an acyclic nucleotide analog that inhibits viral reverse transcriptase. It is utilized in research for studying antiviral mechanisms against hepatitis B and herpes simplex virus, with applications in both in vitro enzyme assays and in vivo animal models of infection.

Research Area

Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 106941-25-7
• MW: 273.19
• Purity: 99.56% (May vary between batches)
• Formula: C₈H₁₂N₅O₄P
• SMILES: CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C
• Target: Telomerase|||Reverse Transcriptase|||HBV
• Solubility: H2O:2.5 mM;DMSO:Insoluble

Bioactivity

• In Vitro:
  adefovir is a potent inhibitor of DHBV replication that inhibits CCC DNA amplification but does not effectively prevent the formation of CCC DNA from incoming viral genomes.
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• Cell Research:
  The effect of adefovir on viral CCC DNA synthesis was examined with primary cultures of DHBV-infected fetal hepatocytes. Adefovir was administered for six consecutive days starting one day before or four days after DHBV inoculation. Dose-dependent inhibition of both virion release in culture supernatants and synthesis of intracellular viral DNA was observed.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

reverse, Reverse Transcriptase, ReverseTranscriptase, PMEA, transcriptase, Telomerase reverse transcriptase, monophosphate, inhibit, HIV, Hepatitis B virus, herpesviruses, HBV, Inhibitor, GS0393, GS-0393, GS 0393, antiviral, Adefovir, adenosine, diphosphate

Compound Identifiers

PubChem CID

60871