Adavivint

SKU: orb1301632

Description

Adavivint (SM04690) is a potent and selective small molecule inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM in a TCF/LEF reporter assay using SW480 cells. It is a valuable research tool for investigating Wnt pathway biology in vitro and has shown potential for modulating bone and cartilage regeneration in preclinical in vivo models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1467093-03-3
• MW: 505.55
• Purity: 99.54% (May vary between batches)
• Formula: C₂₉H₂₄FN₇O
• SMILES: CC(C)CC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4cncc(-c5cccc(F)c5)c4[nH]3)c2c1
• Target: Wnt/beta-catenin
• Solubility: DMSO:16.25 mg/mL (32.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.96 mM)

Bioactivity

• Target IC50:
  Wnt (SW480 cells):19.5 nM (EC50)
• In Vivo:
  Adavivint (SM04690) is a novel Wnt pathway inhibitor, for the treatment of moderate to severe osteoarthritis of the knee.
• Animal Research:
  A high-throughput screen was performed using a cell-based reporter assay for Wnt pathway activity to develop a small molecule designated SM04690. Its properties were evaluated in bone-marrow-derived human mesenchymal stem cells (hMSCs) to assess chondrocyte differentiation and effects on cartilage catabolism by immunocytochemistry and gene expression, and glycosaminoglycan breakdown. In vivo effects of SM04690 on Wnt signaling, cartilage regeneration and protection were measured using biochemical and histopathological techniques in a rodent acute cruciate ligament tear and partial medial meniscectomy (ACLT + pMMx) OA model.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

bcatenin, Adavivint, Adavivint (SM04690), betacatenin, beta-catenin, inhibit, Lorecivivint, Inhibitor, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, SM 04690, SM04690, SM-04690, βcatenin

Compound Identifiers

PubChem CID

135565709