Adarotene

SKU: orb1308690

Description

Adarotene (ST1926) is a synthetic retinoid derivative that potently induces apoptosis and DNA damage, leading to strong antiproliferative effects across diverse human cancer cell lines. Its activity has been demonstrated in vitro and in vivo, supporting research in oncology, chemoprevention, and mechanisms of cell death.

Research Area

Cell Biology

Key Properties

• CAS Number: 496868-77-0
• MW: 374.47
• Purity: 99.68%
• Formula: C₂₅H₂₆O₃
• SMILES: OC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2
• Target: Apoptosis
• Solubility: DMSO:45 mg/mL (120.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.34 mM)

Bioactivity

• In Vivo:
  Adarotene, administered orally at doses of 30 and 40 mg/kg, significantly extends the lifespan of NB4-bearing SCID mice in a dose-dependent manner without apparent toxicity . At lower doses of 15 and 20 mg/kg, it markedly inhibits tumor growth in human ovarian carcinoma (A2780/DX) and human melanoma (MeWo) models in nude mice .
• In Vitro:
  Adarotene causes cell accumulation in the G1/S or S phase of the cell cycle depending on tumor cells IGROV-1 and DU145. Adarotene causes dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 μM . Adarotene is apoptotic and cytotoxic on a large spectrum of cancerous and leukemic cells, including freshly isolated AML blasts in primary culture. Adarotene treatment of cells results in rapid accumulation of intracellular calcium .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Adarotene, inhibit, Inhibitor, ST 1926, ST1926, ST-1926

Compound Identifiers

PubChem CID

9864378