Adaphostin

SKU: orb1704704

Description

Adaphostin (NSC-680410) is a small molecule inhibitor targeting the p210Bcr-Abl tyrosine kinase, exhibiting an IC50 of 14 µM. It has been utilized in research to study chronic myeloid leukemia (CML), demonstrating cytotoxic effects in vitro and showing antitumor activity in preclinical in vivo models.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 241127-58-2
• MW: 393.48
• Purity: 98.29% (May vary between batches)
• Formula: C₂₄H₂₇NO₄
• SMILES: Oc1ccc(O)c(CNc2ccc(cc2)C(=O)OC23CC4CC(CC(C4)C2)C3)c1
• Target: Apoptosis,Bcr-Abl
• Solubility: DMSO:55 mg/mL (139.78 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.08 mM);Ethanol:< 40 mg/mL (101.66 mM)

Bioactivity

• Target IC50:
  p210 (BCR-ABL):14 μM
• In Vivo:
  Adaphostin can damage both myeloid and lymphoid leukemia cells.
• In Vitro:
  It also induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p210Bcr/abl, ROS, tyrosine kinase, 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate, Adaphostin, Apoptosis, Bcr-Abl, BcrAbl, chronic myelogenous leukemia, CML, Inhibitor, inhibit, myeloid, NSC 680410, NSC680410, NSC-680410

Compound Identifiers

PubChem CID

387042