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ADAMTS-5-IN-4

SKU: orb3174996

Description

ADAMTS-5-IN-4 (Compound 4b) is a selective inhibitor of ADAMTS5 with an IC50 of 9.4 μM. It significantly hinders Aggrecan degradation in explant models of osteoarthritis and effectively suppresses pseudopodia extension and directional migration in ovarian cancer cells. ADAMTS-5-IN-4 also exhibits significant cytotoxicity towards HEK293T cells, human chondrocytes, and porcine cartilage explants. This compound is applicable in research related to osteoarthritis and ovarian cancer.

Research Area

Protein Biochemistry

Images & Validation

Key Properties

TargetProtease

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information