ADAM17-IN-1

SKU: orb3173259

Description

ADAM17-IN-1 is a selective ADAM17 inhibitor. It functions by reducing dendritic cell (DC) metabolic activity through ADAM17 inhibition, thereby impairing DC antigen presentation, suppressing allergen-specific Th2 cell polarization, and decreasing the secretion of Th2 cytokines (IL-4, IL-5, IL-13). In mouse models of house dust mite (HDM)-induced type 2/eosinophilic airway inflammation, ADAM17-IN-1 demonstrates protective effects. This compound can be utilized in research on type 2 hyperreactive allergic asthma.

Research Area

Immunology & Inflammation, Protein Biochemistry

Key Properties

• CAS Number: 1802395-34-1
• MW: 669.91
• Formula: C₄₀H₅₅N₅O₄
• SMILES: [C@H](CN1[C@H](CN2[C@@H](CCC)CNC(=O)C2=O)CCC1)(CC3CCCCC3)N4C[C@H](CC5=CC=CC=C5)N(CCC6=CC=CC=C6)C(=O)C4=O
• Target: Interleukin,MMP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,MMP