AD1058

SKU: orb2665507

Description

AD1058 is a brain-penetrant, highly selective ATR inhibitor (IC50 1.6 nM) with demonstrated in vivo antitumor efficacy. It is a key research tool for studying brain/CNS metastases, where it exerts its effects by inhibiting proliferation, arresting the cell cycle, and promoting apoptosis in preclinical models.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2907782-78-7
• MW: 412.47
• Formula: C₁₉H₂₀N₆O₃S
• SMILES: C[C@H]1N(C2=C3C(=NC(=N2)C4=C5C(=NC=C4)NC=C5)N(S(C)(=O)=O)C=C3)CCOC1
• Target: ATM/ATR|||Apoptosis|||Src|||AMPK|||mTOR
• Solubility: DMSO:80 mg/mL (193.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.12 mM)

Bioactivity

• Target IC50:
  LCK:2594.00 nM|ARK5:7314.00 nM|mTOR:45.83 nM|ATR:1.6 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AD 1058, ATM, ATR

Compound Identifiers

PubChem CID

168874317