Acyclovir

SKU: orb1308575

Description

Acyclovir

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59277-89-3
• MW: 225.2
• Purity: >99%
• Formula: C₈H₁₁N₅O₃
• SMILES: NC1=NC(=O)C2=C(N1)N(COCCO)C=N2
• Target: Antibacterial|||HSV|||Antibiotic|||DNA/RNA Synthesis|||Apoptosis
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:42.92 mg/mL (190.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.88 mM)

Bioactivity

• Target IC50:
  HSV2:0.86 μM (IC50)|HSV1:0.85 μM (IC50)
• In Vivo:
  low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections.
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• In Vitro:
  Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA, DNA synthesis, DNA Synthesis, DNASynthesis, Aciclovir, Acycloguanosine, Acyclovir, anti-herpetic, Antibiotic, antibody, Apoptosis, Bacterial, kinase, Inhibitor, immunosuppression, inhibit, Herpes simplex virus, HSV, RNASynthesis, RNA Synthesis, polymerase, thymidine, triphosphate

Compound Identifiers

PubChem CID

135398513