ACT-451840

SKU: orb2893722

Description

ACT-451840 is an orally active, potent, and low-toxicity antimalarial research compound with an artemisinin-like mechanism. It demonstrates rapid action against all asexual blood stages of both sensitive and resistant P. falciparum, showing 99.80% parasite reduction in vivo at 30 mg/kg. This profile supports its investigation for malaria drug discovery and resistance studies.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1984890-99-4
• MW: 750.97
• Purity: 96.07%
• Formula: C₄₇H₅₄N₆O₃
• SMILES: CC(=O)N1CCN(CC1)c1ccc(CN([C@@H](Cc2ccccc2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)C(=O)\C=C\c2ccc(cc2)C(C)(C)C)cc1
• Target: Parasite
• Solubility: DMSO:30 mg/mL (39.95 mM)

Bioactivity

• In Vivo:
  In the in vivo efficacy model, the 90% effective dose against P. falciparum of ACT-451840 was 3.7 mg/kg and the 90% effective dose against P. berghei was 13 mg/kg.
• In Vitro:
  ACT-451840 has a 50% inhibitory concentration of 0.4 nM against the drug-susceptible P. falciparum NF54 strain; ACT-451840 effectively blocks male gamete formation from the gametocyte stage at a 50% inhibitory concentration of 5.89 nM, and blocks mosquito oocyst development in a dose-dependent manner at a 50% inhibitory concentration of 30 nM.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ACT451840

Compound Identifiers

PubChem CID

53303762