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AcrB-IN-4
Catalog Number: orb1982581
| Catalog Number | orb1982581 |
|---|---|
| Category | Small Molecules |
| Description | Efflux pump-IN-4, an AcrB efflux pump inhibitor, potentiate[s] the effects of antibiotics by inhibiting the efflux of Nile Red (a known substrate of AcrB). It does not disrupt the bacterial outer membrane or display toxicity in a nematode model. |
| MW | 506.66 |
| CAS Number | 2890177-95-2 |
| Formula | C29H34N2O4S |
| SMILES | C(=O)(C1=C2C(=C3C(=C1)C(OCCCSC4=CC=C(N)C=C4)=CC=C3)OC(C)(C)CC2)N5CCOCC5 |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.Note:
- For Reference Only. Please choose the appropriate dissolution protocol according to your experimental animal and administration method.
- We suggest that in cell experiments, the final concentration of DMSO is not more than 0.1%, in animal experiments, for healthy mice, the final concentration of DMSO is not more than 10%; For nude or frail mice, the final concentration of DMSO is not more than 2%.
