Acipimox

SKU: orb1224877

Description

Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use. (In Vitro):Acipimox (0-100 μM; 0-4 hours) enhances leptin release from adipocytes isolated from Sprague-Dawley rats in a time- and dose- dependent manner.Acipimox (10 mM) stimulats leptin release in adipocytes from Streptozotocin (STZ)-treated and Zucker diabetic fat (ZDF) rats.(In Vivo):Acipimox (50 mg/kg; i.p.) significantly lowers circulating free fatty acid (FFA) and glucose in high-fat fed mice.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 51037-30-0
• MW: 154.13
• Purity: >98% (HPLC)
• Formula: C₆H₆N₂O₃
• SMILES: O=C(C1=C[N+]([O-])=C(C)C=N1)O
• Target: triglycerides production
• Solubility: DMSO: 31 mg/mL (201.14 mM)

Bioactivity

• In Vivo:
  Acipimox (50 mg/kg; i.p.) significantly lowers circulating free fatty acid (FFA) and glucose in high-fat fed mice. Animal model: Female C57BL/6J mice. Dosage: 50 mg/kg. Administration: Intraperitoneal injection. Result: Reduced circulating levels of FFA and glucose after 3 h.
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• In Vitro:
  Acipimox (0-100 μM; 0-4 hours) enhances leptin release from adipocytes isolated from Sprague-Dawley rats in a time- and dose- dependent manner. Acipimox (10 mM) stimulats leptin release in adipocytes from Streptozotocin (STZ)-treated and Zucker diabetic fat (ZDF) rats.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Acipimox | K-9321 | K9321 | K 9321 | Olbemox | Olbetam

Quick Database Links

Gene Symbol

triglycerides production