Acetoacetyl Coenzyme A sodium hydrate

SKU: orb1693408

Description

Acetoacetyl Coenzyme A sodium hydrate is a key metabolic intermediate serving as a direct precursor for the biosynthesis of poly-β-hydroxybutyrate (PHB). It is widely used in vitro to study enzymatic pathways in lipid metabolism and bacterial PHB production, as well as in investigations of cellular energy homeostasis.

Key Properties

• MW: 989.61
• Formula: C₂₅H₄₅N₇Na₃O₂₂P₃S
• SMILES: O[C@H]1[C@@H](O[C@@H]([C@H]1OP(O)([O-])=O)COP(OP(OCC(C)([C@H](C(NCCC(NCCSC(CC(C)=O)=O)=O)=O)O)C)([O-])=O)([O-])=O)N2C=NC3=C2N=CN=C3N.[Na+].[Na+].[Na+].O.O.O.O
• Target: Others
• Solubility: H2O:8 mg/mL (8.08 mM);PBS (pH 7.2):10 mg/mL (10.1 mM)

Bioactivity

• Target IC50:
  Acetate:0.021 mM (Km)|Propionate:0.007 mM (Km)|Butyrate:0.056 mM (Km)
• In Vitro:
  Km values for Acetoacetyl Coenzyme A sodium hydrate, acetate, and propionate were calculated from intercept and slope replots. The Km, values for Acetoacetyl Coenzyme A the acetate as substrate were 0.021 mM. The Km, values for Acetoacetyl Coenzyme A the propionate as substrate were 0.007 mM. The Km, values for Acetoacetyl Coenzyme A the butyrate as substrate were 0.056 mM. The Km, values for the carboxylic acids were remarkably high.

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

sodium Hydrate, Acetoacetyl Coenzyme A, Acetoacetyl Coenzyme A (sodium salt hydrate), Acetoacetyl-CoA, Acetoacetyl-CoA sodium hydrate

Compound Identifiers

PubChem CID

132285235