Acalabrutinib maleate

SKU: orb3174808

Description

Acalabrutinib maleate is an orally active, irreversible, highly selective second-generation BTK inhibitor. It forms a covalent bond with the Cys481 residue in the ATP-binding pocket of BTK. This compound demonstrates potent targeting effects and activity in a murine model of chronic lymphocytic leukemia (CLL) and is used in CLL research. Acalabrutinib maleate acts as a click chemistry reagent, containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.

Key Properties

• CAS Number: 2242394-65-4
• MW: 581.59
• Formula: C₃₀H₂₇N₇O₆
• SMILES: C(=C\C(O)=O)\C(O)=O.C(C#CC)(=O)N1[C@H](C=2N3C(=C(N2)C4=CC=C(C(NC5=CC=CC=N5)=O)C=C4)C(N)=NC=C3)CCC1
• Target: BTK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

BTK