AC710

SKU: orb1296109

Description

AC710 is a potent small molecule inhibitor targeting PDGFRs, with high affinity for FLT3, KIT, CSF1R, PDGFRα, and PDGFRβ (Kd values 0.6-1.57 nM). It is a valuable research tool for studying receptor tyrosine kinase signaling in oncology and hematology research, applicable in both cellular and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1351522-04-7
• MW: 562.7
• Purity: 99.67%
• Formula: C₃₁H₄₂N₆O₄
• SMILES: CCN1C(C)(C)CC(CC1(C)C)Oc1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
• Target: c-Kit,FLT,PDGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (0.89 mM);DMSO:15 mg/mL (26.66 mM)

Bioactivity

• Target IC50:
  PDGFRα:1.3 nM (Kd)|CSF1R:1.57 nM (Kd)|PDGFRβ:1 nM (Kd)|FLT3:0.6 nM (Kd)|c-Kit:1 nM (Kd)
• In Vivo:
  At a dosage of 0.3 mg/kg, AC710 transiently inhibits tumor growth, with rapid resumption following cessation. Doses of 3 and 30 mg/kg result in complete tumor regression and prolonged suppression of tumor volume post-treatment. Notably, administration of AC710 does not lead to bodyweight loss in treated animals across all tested doses. Further, AC710 significantly mitigates disease progression in a mouse collagen-induced arthritis (CIA) model in a dose-dependent manner, starting from a low dose of 3 mg/kg over a span of 15 days (day 0-14). At increased dosages of 10 and 30 mg/kg, AC710's effectiveness in reducing joint swelling and inflammation is comparable or slightly superior to that of dexomethasone administered at a safe dose.
• Animal Research:
  The antitumor efficacy of AC710 is assessed in a subcutaneous flank-tumor xenograft model in athymic nude mice using the MV4-11cell line. AC710 is dosed at 0.3, 3, and 30 mg/kg for 2 weeks. Tumor growth and body weight are monitored.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CD135, Cluster of differentiation antigen 135, CD117, cKit, c-Kit, AC710, AC-710, AC 710, FLT3, Fms like tyrosine kinase 3, Inhibitor, inhibit, Kit, Platelet-derived growth factor receptor, PDGFR, PDGFRβ, PDGFRα, SCFR

Compound Identifiers

PubChem CID

54760053