Ac-YVAD-CMK

SKU: orb1693818

Description

Ac-YVAD-CMK is a potent, irreversible, and selective caspase-1 inhibitor that effectively blocks pyroptosis and the maturation of IL-1β/IL-18. This neuroprotective and anti-inflammatory compound is widely used in research models, including studies of inflammatory diseases and neuroinflammation in both cellular and animal systems.

Research Area

Cell Biology, Immunology & Inflammation, Protein Biochemistry

Key Properties

• Target: Pyroptosis,Immunology/Inflammation related,IL Receptor,Caspase
• CAS Number: 178603-78-6
• MW: 540.99
• Purity: 97.08% (May vary between batches)
• Formula: C₂₄H₃₃ClN₄O₈
• SMILES: CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CCl

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Caspase-1, Caspase-1 Inhibitor II, Ac-YVAD-CMK, Ac-Tyr-Val-Ala-Asp-chloromethylketone, Ac-Tyr-Val-Ala-Asp-CMK, Immunology related, Immunologyrelated, inflammation, Inflammation related, Inflammationrelated, ILReceptor, IL-1β, IL Receptor, Pyroptosis

Compound Identifiers

PubChem CID

9915279