Ac-Ile-Glu-Thr-Asp-pNA

• Catalog Number: orb1984620
• Category: Small Molecules
• Description: Ac-Ile-Glu-Thr-Asp-pNA is a caspase-8 substrate that undergoes enzymatic binding and cleavage specifically at the Ile-Glu-Thr-Asp (IETD) peptide sequence, resulting in the release of p-nitroalinide, which can be quantitatively measured using colorimetric detection at 405 nm as an indicator of caspase-8 enzyme activity.
• Purity: 98.00%
• MW: 638.62
• Biological Activity: Ac-Ile-Glu-Thr-Asp-pNA is a caspase-8 substrate that undergoes enzymatic binding and cleavage specifically at the Ile-Glu-Thr-Asp (IETD) peptide sequence. This cleavage results in the release of p-nitroalinide, which can be quantitatively measured using colorimetric detection at 405 nm. This measure serves as an indicator of caspase-8 enzyme activity.
• CAS Number: [219138-21-3]
• Formula: C₂₇H₃₈N₆O₁₂
• SMILES: CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O
• Storage: -20°C
• Note: For research use only