Ac-Exatecan

SKU: orb2944177

Description

Ac-Exatecan is an acetylated derivative of the topoisomerase I inhibitor Exatecan (DX-8951), which exhibits antitumor activity with an IC50 of 2.2 μM. This compound is utilized in cancer research to study TOP1 inhibition and has been investigated in both in vitro cytotoxicity assays and in vivo tumor model studies.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2922852-48-8
• MW: 477.48
• Purity: 97.09% (May vary between batches)
• Formula: C₂₆H₂₄FN₃O₅
• SMILES: N(C(C)=O)[C@@H]1C2=C3C(C=4N(C3)C(=O)C5=C(C4)[C@](CC)(O)C(=O)OC5)=NC=6C2=C(CC1)C(C)=C(F)C6
• Target: ADC Cytotoxin,Topoisomerase
• Solubility: DMSO:80 mg/mL (167.55 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Cytotoxin, ADCCytotoxin, Ac-DX-8951

Compound Identifiers

PubChem CID

124411986