AC-262536

SKU: orb1305214

Description

AC-262536 is a potent and selective androgen receptor modulator (SARM) with partial agonist activity relative to testosterone. It demonstrates luteinizing hormone suppression and is utilized in research exploring muscle wasting, osteoporosis, and androgen receptor pharmacology in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 870888-46-3
• MW: 278.35
• Purity: 99.88%
• Formula: C₁₈H₁₈N₂O
• SMILES: O[C@@H]1C[C@@H]2CC[C@H](C1)N2c1ccc(C#N)c2ccccc12
• Target: Androgen Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (3.59 mM);DMSO:50 mg/mL (179.63 mM)

Bioactivity

• In Vivo:
  In male sprague-dawley rats, administration of AC-262536 (subcutaneous injection, once daily for 14 consecutive days) significantly decreased LH levels by about 40% at the 3 mg/kg dose. At the 10 and 30 mg/kg doses, the effects of AC-262536 were significantly stronger than Testosterone Propionate (TP) : 1.91±0.32 ng/mL and 1.53±0.34 ng/mL vs. 3.12±0.69 ng/mL, respectively.
• In Vitro:
  AC-262536 inhibits dihydroxytestosterone (DHT)-induced proliferation of LNCaP in a dose-dependent manner. The effects are significant with 100 nM, and reaches a plateau with 1 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SARM, receptor, Inhibitor, non-steroidal, inhibit, modulator, AC 262536, AC262536, AC-262536, anabolic, androgen, AndrogenReceptor, Androgen Receptor

Compound Identifiers

PubChem CID

44512434