AC 187 Acetate

SKU: orb1306289

Description

AC 187 Acetate is a potent and selective amylin receptor antagonist, exhibiting greater specificity for amylin receptors over related calcitonin and CGRP receptors. This tool compound is widely used in metabolic research, particularly in vitro binding assays and in vivo studies investigating amylin's role in energy homeostasis and glucose metabolism.

Research Area

Pharmacology & Drug Discovery

Key Properties

• MW: 2950.26
• Purity: 99.71% (May vary between batches)
• Formula: C₁₂₉H₂₀₉N₃₇O₄₂
• SMILES: O=C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC2=CC=C(C=C2)O)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC4=CC=C(C=C4)O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C.CC(O)=O
• Target: Amylin Receptor
• Solubility: H2O:90 mg/mL (30.51 mM)

Bioactivity

• Target IC50:
  Amylin receptor:0.48 nM
• In Vitro:
  AC187 attenuates the activation of initiator and effector caspases that mediate Aβ-induced apoptotic cell death.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AmylinReceptor, Amylin Receptor, amylin, 151804-77-2, 151804-77-2 Free base, AC 187 Acetate, AC 187 Acetate (151804-77-2 Free base), AC187 Acetate, AC-187 Acetate

Compound Identifiers

PubChem CID

163285766