Abemaciclib metabolite M18

SKU: orb1983366

Description

M18 (LSN3106729), an active metabolite of abemaciclib, is a potent CDK4/6 inhibitor. It has been utilized as a warhead in the design of CRBN-based PROTAC molecules, enabling targeted degradation of CDK4/6 proteins for research in oncology and cellular proliferation studies.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2704316-81-2
• MW: 494.54
• Formula: C₂₅H₂₈F₂N₈O
• SMILES: C(C)(C)N1C=2C(N=C1CO)=C(F)C=C(C2)C3=NC(NC4=CC=C(CN5CCNCC5)C=N4)=NC=C3F
• Target: Ligands for Target Protein for PROTAC,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145925652