ABC99

SKU: orb1305597

Description

ABC99 is a potent and selective irreversible inhibitor of the NOTUM carboxylesterase, a key enzyme that deacylates Wnt proteins. With an IC50 of 13 nM and excellent selectivity over other serine hydrolases, it is a valuable chemical probe for investigating Wnt signaling pathways in both cellular and animal models of development and disease.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2331255-53-7
• MW: 456.88
• Purity: 99.89% (May vary between batches)
• Formula: C₂₂H₂₁ClN₄O₅
• SMILES: Clc1ccc(CN2CCN3C(C2)C(=O)N(OC(=O)N2CCOc4ccccc24)C3=O)cc1
• Target: Wnt/beta-catenin
• Solubility: DMSO:20 mg/mL (43.78 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.38 mM)

Bioactivity

• In Vitro:
  ABC99 (0.1~10 μM; 2 hours; SW620 cells) inhibits NOTUM and preserves Wnt-3A activity in a concentration-dependent manner .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ABC-99, ABC99, ABC 99, bcatenin, beta-catenin, betacatenin, Wnt/β-catenin, Wnt, Wnt/betacatenin, Wnt/b-catenin, βcatenin

Compound Identifiers

PubChem CID

134817170