AB25583

SKU: orb2665511

Description

AB25583 is a potent and selective Polθ helicase inhibitor (IC50 = 6 nM) developed for cancer research. It exhibits synthetic lethality in BRCA1/2-deficient cells and synergizes with PARP inhibitors like Olaparib, supporting its investigation in both in vitro and in vivo models of homologous recombination-deficient cancers.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2565637-94-5
• MW: 452.91
• Formula: C₂₂H₁₇ClN₄O₃S
• SMILES: O=C(NC1=NN=C(OCC2=CC=C(Cl)C=C2)S1)C=3C=NC=CC3C=4C=CC=CC4OC
• Target: DNA/RNA Synthesis,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155342563