AAL-993

SKU: orb1306284

Description

AAL-993 is a selective VEGFR inhibitor with IC50 values of 130 nM (VEGFR1), 23 nM (VEGFR2), and 18 nM (VEGFR3). It exhibits potent antiangiogenic and antitumor activity in preclinical models, making it a useful research tool for studying tumor angiogenesis and metastasis in both cellular and animal studies.

Research Area

Cardiovascular Research

Key Properties

• CAS Number: 269390-77-4
• MW: 371.4
• Purity: >98%
• Formula: C₂₀H₁₆F₃N₃O
• SMILES: FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
• Target: Kinase
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).

Bioactivity

• Target IC50:
  VEGFR1:130 nM|VEGFR2:23 nM|VEGFR3:18 nM
• In Vivo:
  AAL993 (24-100 mg/kg; p.o.) inhibited both the growth of the primary tumor as well as the formation of spontaneous peripheral metastases in B16 melanoma xenograft model. AAL993 potently inhibited VEGF-induced angiogenesis with an ED50 value of 7 mg/kg in an implant model.
• In Vitro:
  AAL993 suppressed HIF-1α expression through the inhibition of ERK without affecting Akt phosphorylation.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AAL993, AAL-993, AAL 993, antiangiogenic, antitumor properties, inhibit, orally active, Inhibitor, VEGFR3, VEGFR inhibitor, VEGFR2, VEGFR, VEGFR1, Vascular endothelial growth factor receptor

Compound Identifiers

PubChem CID

6398883