AAK1/HDACs-IN-1 (Compound 12) is a potent dual inhibitor of AAK1, HDAC1, and HDAC6 with IC50 values of 15.9, 148.6, and 5.2 nM, respectively. It has demonstrated antiviral activity in vitro by inhibiting SARS-CoV-2 entry through disruption of clathrin-mediated endocytosis, making it a useful research tool for studying viral infection pathways and epigenetic regulation.