A939572

SKU: orb1302794

Description

A939572

Research Area

Metabolism Research

Key Properties

• CAS Number: 1032229-33-6
• MW: 387.86
• Purity: 99.96%
• Formula: C₂₀H₂₂ClN₃O₃
• SMILES: CNC(=O)c1cccc(NC(=O)N2CCC(CC2)Oc2ccccc2Cl)c1
• Target: Stearoyl-CoA Desaturase (SCD),Dehydrogenase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.16 mM);DMSO:45 mg/mL (116.02 mM)

Bioactivity

• Target IC50:
  SCD1 (mouse) < nM |SCD1 (human):37 nM
• In Vivo:
  Athymic nude (nu/nu) mice bearing A498 ccRCC xenografts were treated with A939572 and Tem individually or in combination over the course of four weeks, and tumor volume (mm3) was recorded. A939572 and Tem monotherapy generated similar growth responses with approximately 20-30% reductions in tumor volume (vs. placebo control) being observed upon study completion, with Values reaching statistical significance only within the last week of treatment. the combination group yielded over a 60% decrease in tumor volume (vs. placebo control) by study completion with significant reductions recorded after approximately 1 week of treatment. All of the animals maintained a healthy weight throughout the course of the treatment, however those In both the A939572 and the Combo group exhibited increased blinking, and slight mucosal discharge from the eyes after the first week of treatment.
• In Vitro:
  A939572 has been used to induce cell death of hPSCs as well as to inhibi the proliferation of human non-s All cell lung carcinoma H1299 cells in vitr [1.
• Animal Research:
  A498 cells were Subcutaneously implanted in athymic nu/nu mice at × 0^6 cells/mouse in 50%Matrigel. Tumors reached ~50 mm^3 prior to 4wk treatment. A939572 was re-suspended in strawberry-flavored Kool-Aid in sterilized H2O (0.2g/mL) Vehicle at 3 mg/kg in a 50μl dose. Mice were orally fed by using a syringe to administe the 50μl dose twice daily/mouse. This modified method was found to be effective and less stressful o the mice. Temsirolimus was solubilized in 30% ethanol/saline and administered via intraperitoneal injection at 1 mg/kg in a 50μl dose once every 72hrs/mouse. Tumor volumes were calculated usin the formula and body weight were measured every 3 day.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

A939572, A-939572, A 939572, inhibit, Inhibitor, SCD, SCD1 (human), SCD1 (mouse), Stearoyl-CoA Desaturase, StearoylCoA Desaturase (SCD), StearoylCoADesaturase(SCD), Stearoyl-CoA Desaturase (SCD), StearoylCoADesaturase

Compound Identifiers

PubChem CID

24905400