A2073

SKU: orb3135625

Description

A2073 is a flavonoid derivative that inhibits the proliferation of erythroleukemia cells by inducing cell cycle arrest and suppressing the MAPK, NF-κB, and PI3K signaling pathways. It forms stable interactions with cell cycle-related proteins (CDK1, CCNA2, PRIM1). In a zebrafish xenograft tumor model, A2073 demonstrates significant anti-tumor cell proliferation activity while maintaining low toxicity. A2073 is suitable for research in acute erythroleukemia.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2834742-70-8
• MW: 559.65
• Formula: C₃₃H₃₇NO₇
• SMILES: O[C@]12[C@]([C@@H](C[C@H]1OC(CN3CCCCC3)=O)C4=CC=CC=C4)(OC=5C2=C(OC)C=C(OC)C5)C6=CC=C(OC)C=C6
• Target: p38 MAPK,NF-κB,Akt,PI3K

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

p38 MAPK,NF-κB,Akt,PI3K