A-9758

• Catalog Number: orb1710516
• Category: Small Molecules
• Description: A-9758
• CAS Number: 2055271-22-0
• Purity: 98%
• MW: 527.36
• SMILES: CN1C=2C(C=C1CC3=C(Cl)C(C(=O)N4CCC(C(O)=O)CC4)=CC=C3Cl)=C(C)C=C(C(F)(F)F)C2
• Formula: C₂₅H₂₃Cl₂F₃N₂O₃
• Biological Activity: A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.