A-9758

SKU: orb1710516

Description

A-9758 is a potent and selective RORγt inverse agonist (IC50 = 5 nM) that effectively inhibits IL-17A release. It suppresses Th17 cell differentiation and function, and has demonstrated efficacy in reducing psoriasiform skin inflammation in an IL-23-driven in vivo model.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 2055271-22-0
• MW: 527.36
• Formula: C₂₅H₂₃Cl₂F₃N₂O₃
• SMILES: CN1C=2C(C=C1CC3=C(Cl)C(C(=O)N4CCC(C(O)=O)CC4)=CC=C3Cl)=C(C)C=C(C(F)(F)F)C2
• Target: Interleukin,ROR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

124123531