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A-967079

SKU: orb1226887

Description

A potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively; displays >1,000-fold selective over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes, and G-protein-coupled receptors; exhibits analgesic efficacy in allyl isothiocyanate-induced nocifensive response and osteoarthritic pain in rats (ED50=23.2 mg/kg), attenuates cold allodynia produced by nerve injury but does not alter noxious cold sensation in naive animals; orally bioavailable.Pain Preclinical

Images & Validation

Key Properties

CAS Number1170613-55-4
MW207.24
Purity>98% (HPLC)
FormulaC12H14FNO
SMILESCCC(/C(C)=C/C1=CC=C(F)C=C1)=N\O
TargetTRP/TRPV Channel
SolubilityDMS : 100 mg/mL482.53 mM;H2O : < 0.1 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

A967079 | A 967079

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A-967079 (orb1226887)

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200 mg
500 mg
5 mg
$ 100.00
10 mg
$ 120.00
25 mg
$ 220.00
50 mg
$ 370.00
100 mg
$ 610.00