A-967079

SKU: orb1226887

Description

A potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively; displays >1,000-fold selective over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes, and G-protein-coupled receptors; exhibits analgesic efficacy in allyl isothiocyanate-induced nocifensive response and osteoarthritic pain in rats (ED50=23.2 mg/kg), attenuates cold allodynia produced by nerve injury but does not alter noxious cold sensation in naive animals; orally bioavailable.Pain Preclinical

Key Properties

• CAS Number: 1170613-55-4
• MW: 207.24
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₄FNO
• SMILES: CCC(/C(C)=C/C1=CC=C(F)C=C1)=N\O
• Target: TRP/TRPV Channel
• Solubility: DMS : 100 mg/mL482.53 mM;H2O : < 0.1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A967079 | A 967079

Quick Database Links

Gene Symbol

TRP/TRPV Channel