A-86929

SKU: orb3028567

Description

A-86929 is a potent and selective dopamine D1 receptor agonist with a pKi of 7.3. It significantly induces rotational behavior in a 6-OHDA-induced unilateral nigral lesion rat model and improves motor function in an MPTP-induced Parkinson's disease marmoset model. Furthermore, A-86929 shows potential value in reducing cocaine-induced craving behavior in rats and reversing Haloperidol-induced cognitive deficits in rhesus monkeys. The compound is useful for researching neurological disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 171961-95-8
• MW: 315.43
• Formula: C₁₈H₂₁NO₂S
• SMILES: C(CC)C1=CC=2[C@@]3(C=4C(CC[C@]3(NCC2S1)[H])=CC(O)=C(O)C4)[H]
• Target: Dopamine Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Dopamine Receptor