A 83586C

SKU: orb1986986

Description

A-83586C is a Streptomyces-derived depsipeptide antibiotic with potent in vitro activity against Gram-positive bacteria. This compound is a research tool that potently inhibits β-catenin/TCF4 signaling and E2F-mediated transcription in cancer cells, downregulating targets like osteopontin and E2F1 while modulating retinoblastoma protein phosphorylation. Its mechanisms support investigations in oncology, particularly in Wnt signaling and cell cycle pathways.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 116364-81-9
• MW: 977.15
• Formula: C₄₇H₇₆N₈O₁₄
• SMILES: [C@@](C(N[C@H]1[C@H](C(C)C)OC(=O)[C@@]([C@H](C)O)(NC(=O)[C@]2(N(C(=O)[C@@H](C)N(C)C(=O)[C@H](C)N(O)C(=O)[C@@]3(N(C1=O)NCCC3)[H])NCCC2)[H])[H])=O)(CC)(O)[C@]4(O)O[C@H](\C(=C\[C@@H](C(/C(=C/C)/C)=O)C)\C)[C@@H](C)CC4
• Target: Others,Antibacterial,Antibiotic

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

6449925