A 438079 hydrochloride

SKU: orb1305183

Description

A 438079 hydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 899431-18-6
• MW: 342.61
• Purity: 99.89%
• Formula: C₁₃H₁₀Cl₃N₅
• SMILES: Cl.Clc1cccc(-c2nnnn2Cc2cccnc2)c1Cl
• Target: P2X Receptor
• Solubility: H2O:1.7 mg/mL (4.96 mM);DMSO:34.3 mg/mL (100.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.84 mM)

Bioactivity

• Target IC50:
  P2X7:6.9( IC50
• In Vivo:
  A-438079 demonstrates selectivity toward the P2X7 receptor at concentration of up to 100 μM. It effectively inhibits Changes in intracellular calcium concentration induced by 10 μM BzATP in 1321N1 cells stably expressin the rat P2X7 receptor, with an IC50 of 321 nM.
• In Vitro:
  A-438079 ha the capability to partially, yet significantly, inhibi the depletion of striatal dopamine (DA) levels induced by 6-OHDA. Pretreatment with A-438079 reduce the pain behavior index in the HC model. Intraperitoneal injection of A-438079 (5 and 15 mg/kg) 60 minutes post-epileptic seizure onset diminishe the severity of epileptic episodes and neuronal death withi the hippocampus. Additionally, intravenous administration of 80 μM L/kg A-438079 in a neuropathic rat model significantly reduces both noxious and innocuous evoked activities in various categories of spinal neurons.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, A438079, A-438079, A-438079 HCl, A438079 Hydrochloride, A-438079 Hydrochloride, A-438079 hydrochloride, A 438079, A 438079 (hydrochloride), A 438079 hydrochloride, A 438079 Hydrochloride, P2X7, P2XReceptor, P2XRs, P2X Receptor

Compound Identifiers

PubChem CID

11688742