A 410099.1

• Catalog Number: orb1693356
• Category: Small Molecules
• Description: A 410099.1
• CAS Number: 762274-58-8
• Purity: 98%
• MW: 505.1
• SMILES: Cl.CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCCc2ccccc12 |@:9|
• Formula: C₂₇H₄₁ClN₄O₃
• Biological Activity: High affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.