A-317491

SKU: orb1218002

Description

A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.

Key Properties

• CAS Number: 475205-49-3
• MW: 565.57
• Purity: >98% (HPLC)
• Formula: C₃₃H₂₇NO₈
• SMILES: O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[C@H]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O
• Target: P2 Receptor
• Solubility: DMSO : 47 mg/mL (83.10 mM); H2O : < 0.1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  Animal model: Male adult Sprague-Dawley rats received an intraplantar injection of Freund's complete adjuvant. Dosage: 0.1, 1, 3, 10, 30 mg/kg. Administration: A single s. c. Result: Produced a dose-dependent reduction in mechanical hyperalgesia 1 h, 3 h and 5 h post-administration.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ABT 202

Quick Database Links

Gene Symbol

P2 Receptor