A-3 hydrochloride

SKU: orb1308708

Description

A-3 hydrochloride is a cell-permeable, ATP-competitive kinase antagonist with broad selectivity. It potently inhibits PKA, CKII, and MLCK, and also blocks PKC and casein kinase I. This compound is a valuable research tool for studying kinase signaling pathways in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin, Metabolism Research, Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 78957-85-4
• MW: 321.22
• Purity: 99.32% (May vary between batches)
• Formula: C₁₂H₁₄Cl₂N₂O₂S
• SMILES: Cl.NCCNS(=O)(=O)c1cccc2c(Cl)cccc12
• Target: PKA,CaMK,PKC,Casein Kinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.45 mM);DMSO:125 mg/mL (389.14 mM)

Bioactivity

• Target IC50:
  CK1:80 μM （ki）|CK2:5.1 μM （ki）|PKA:4.3 μM （ki）|PKC:47 μM （ki）
• In Vitro:
  A-3 hydrochloride competitively inhibits MLC-kinase with respect to ATP, with a Ki value of 7.4 μM. It also competitively inhibits cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II with ATP, exhibiting Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MLC-kinase, kinase, inhibit, inhibitor, A 3, A 3 hydrochloride, A 3 Hydrochloride, A-3, A3 Hydrochloride, A3 hydrochloride, A-3 Hydrochloride, cAMP, CaMK, calmodulin, Calmodulin-dependent kinases, Calmodulin-dependent protein kinases, casein, CaseinKinase, Casein Kinase, CK1, CK2, PKA, PKC, Protein kinase A, Protein kinase C

Compound Identifiers

PubChem CID

9861903