A-1331852

SKU: orb1300501

Description

A-1331852

Research Area

Cell Biology

Key Properties

• CAS Number: 1430844-80-6
• MW: 658.81
• Purity: 98.15%
• Formula: C₃₈H₃₈N₆O₃S
• SMILES: Cc1c(cnn1CC12CC3CC(CC(C3)C1)C2)-c1ccc(nc1C(O)=O)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1
• Target: Bcl-2 Family
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:150 mg/mL (227.68 mM)

Bioactivity

• Target IC50:
  BCL-W:4 nM (Ki)|Bcl-2:6 nM (Ki)|BCL-XL:0.01 nM (Ki)|MCL1:142 nM (Ki)
• In Vivo:
  A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model, inducing tumor regressions as a Single agen.
• In Vitro:
  A-1331852 exhibits remarkable potency both as a Single agent and in combination with TKIs in killing Primary CD34+ mL cell. Also, It has remarkable potency in inducing apoptosis in these cells at low nanomolar concentration as early as 1 h post-treatmen.
• Cell Research:
  Immunoprecipitation of BCL-XL is carried out in K562 cells, exposed to A-1331852 (100 nM) for 0-2 h, an the eluted complexes are immunoblotted fo the indicated proteins the input cell lysates an the immunodepleted supernatant (labeled as Flow-through) are immunoblotted to chec the efficiency o the immunoprecipitation. (Only for Reference)
• Animal Research:
  Mice the growth Inhibition of established tumors in SCID-bg mice is studied. A-1331852 is administered orally daily for 14 days at 25 mg/kg and docetaxel is administered intravenously at 7.5 mg/kg the change of tumor volume is monitored daily. They are for reference only.

Storage & Handling

• Storage: store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Mcl-1, Inhibitor, inhibit, A1331852, A-1331852, A 1331852, Bcl-2, Bcl-2 Family, Bcl-W, BCL-XL

Compound Identifiers

PubChem CID

71565985