A-1248767

SKU: orb2663629

Description

A-1248767 is a potent and selective MCL-1 inhibitor (IC50=23.9 nM; Ki=0.41 nM) derived from A-1210477. It exhibits high-affinity binding, induces intracellular MCL-1 protein stabilization, and triggers apoptosis in cancer cells, supporting its use in oncology research for in vitro and in vivo mechanistic and therapeutic studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 2228052-38-6
• MW: 813.98
• Formula: C₄₇H₅₅N₇O₆
• SMILES: O=C(O)C1=C(C=2C=CC=C(C=3C(=NN(C3C)C)COC4=CC=C(C=C4)N5CCN(C(=O)N(C)C)CC5)C2N1CCN6CCOCC6)CCCOC7=CC=CC=8C=CC=CC78
• Target: Bcl-2 Family,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

134576153