A 1120

SKU: orb1310034

Description

A 1120 is a potent, nonretinoid antagonist of retinol-binding protein 4 (RBP4) with a Ki of 8.3 nM. It functions by disrupting the RBP4-transthyretin complex. This tool compound is used in research to investigate RBP4's role in metabolic diseases, including diabetes and fatty liver, in both cellular and animal models.

Key Properties

• CAS Number: 1152782-19-8
• MW: 392.37
• Purity: 99.47% (May vary between batches)
• Formula: C₂₀H₁₉F₃N₂O₃
• SMILES: OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
• Target: Others
• Solubility: DMSO:95 mg/mL (242.12 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (8.41 mM)

Bioactivity

• Target IC50:
  RBP4:ki:8.3 nM
• In Vitro:
  The IC50 of A 1120 is 66 nM on mouse RBP4 and 90 nM on human RBP4 .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A 1120, A1120, A-1120, inhibit, Inhibitor, RBP4

Compound Identifiers

PubChem CID

25138295