A 1070722

SKU: orb1940835

Description

A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.(In Vivo):PET imaging experiments in anesthetized vervet/African green monkey exhibited that A 1070722 penetrated the blood-brain barrier (BBB) and accumulated in brain regions, with highest radioactivity binding in frontal cortex followed by parietal cortex and anterior cingulate, and with the lowest bindings found in caudate, putamen, and thalamus, similarly to the known distribution of GSK-3 in human brain.

Key Properties

• CAS Number: 1384424-80-9
• MW: 362.312
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₃F₃N₄O₂
• SMILES: COc1ccc2c(NC(=O)Nc3cccc(n3)C(F)(F)F)ccnc2c1
• Target: GSK-3
• Solubility: In Vitro: DMSO : 83.33 mg/mL (230.00 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GSK-3